If you haven't already, check out this article from the Open Medicine Foundation (OMF). It starts with a general overview of theories of the role of viruses in ME and various approaches to treating the viral component of ME. But it's conclusion is perhaps the most interesting. The article concludes that using antiviral treatments for ME may help improve symptoms in patients, but not because antivirals actually decrease viral titers, but because they improve metabolic function. Again, this seems unproven and possibly speculative at this point, but it does seem to reconcile the puzzling results of some studies on the use of antivirals in ME treatment.